منابع مشابه
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia
Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the effects of 2-ME on cell growth, apoptosis, hypoxia-inducible factor 1α (HIF-1α)...
متن کاملGain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes.
PURPOSE Adaptation to host immune surveillance is now recognized as a hallmark of cancer onset and progression, and represents an early, indispensable event in cancer evolution. This process of evolution is first instigated by an immune selection pressure imposed by natural host surveillance mechanisms and may then be propagated by vaccination or other types of immunotherapy. EXPERIMENTAL DES...
متن کاملCOPD, normoxia, and early desaturation.
This duration may appear to be short. The BLUE protocol was performed by experienced operators it is true, but this was done with the aim of not interfering with the management that was underway. Doctors integrating the BLUE protocol in patient management are free to take more time. Several points explain our data, however. Since 1992, we have labeled our whole-body approach “fast-echo” because...
متن کاملNeurones to Normoxia and Hypoxia
1. Exposure of 10 R3-R13 neurones to a 115-min period of hypoxia resulted in depolarization of their membrane potentials (EM) from a mean of -46-9 ± 3-1 to-20-8 ± 4-4mV (S.E.). 2. Intracellular potassium ion activities (a^) decreased significantly from 118-9 ± 5 1 to 67-7 ± 8-5rnM-K. This is equivalent to a change in EKirom — 70-9 mV to —54-5 mV, which is insufficient to account for depolarizat...
متن کاملPhysiological normoxia and chondrogenic potential of chondrocytes.
Cartilage is poorly vascularised with a limited capacity for repair following damage. The poor vascularisation results in cartilage tissue having a low normoxic value. This study examined and compared the effects of physiological cartilage normoxia (2% O2), hypoxia (0.2% O2), and hyperoxia (21% O2) on human articular chondrocytes (hAC) during similar time courses to those prior to transplant in...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2010
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.036772